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Abstract
Glycophagy dysregulation is associated with impaired diastolic relaxation in diabetic heart disease.
- Diabetic heart disease is characterized by early impaired diastolic relaxation.
- Glycogen accumulation and disrupted glycogen autophagy have been found in the diabetic heart.
- The glycogen receptor protein STBD1 is mobilized early in response to metabolic challenges.
- Deficiency of the ATG8 family protein GABARAPL1 is linked to diastolic dysfunction in diabetes.
- Gene delivery of GABARAPL1 improved cardiac diastolic function in type 2 diabetic mice.
- Diastolic performance was enhanced in human stem cell-derived cardiac organoids with GABARAPL1 treatment.
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