Targeted pathophysiological treatment of ischemic stroke using nanoparticle-based drug delivery system

Aug 20, 2024Journal of nanobiotechnology

Using nanoparticles to deliver targeted treatment for stroke caused by blocked blood flow

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Abstract

-based drug delivery systems may enhance treatment outcomes for .

Ischemic stroke is associated with high mortality and disability rates globally.
Limited efficacy of current therapeutic agents poses a challenge in treating ischemic stroke.
Nanoparticles have unique properties that allow them to cross the blood-brain barrier.
Pathophysiological mechanisms involved in ischemic stroke include oxidative stress, glutamate excitotoxicity, neuroinflammation, and cell death.
The classification of nanoparticle-based drug delivery systems according to these mechanisms aids in targeting specific physiological pathways.
The review discusses potential benefits and challenges of using nanoparticles in ischemic stroke treatment.

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poses significant challenges in terms of mortality and disability rates globally. A key obstacle to the successful treatment of ischemic stroke lies in the limited efficacy of administering therapeutic agents. Leveraging the unique properties of for brain targeting and crossing the blood-brain barrier, researchers have engineered diverse nanoparticle-based drug delivery systems to improve the therapeutic outcomes of ischemic stroke. This review provides a concise overview of the pathophysiological mechanisms implicated in ischemic stroke, encompassing oxidative stress, glutamate excitotoxicity, neuroinflammation, and cell death, to elucidate potential targets for nanoparticle-based drug delivery systems. Furthermore, the review outlines the classification of nanoparticle-based drug delivery systems according to these distinct physiological processes. This categorization aids in identifying the attributes and commonalities of nanoparticles that target specific pathophysiological pathways in ischemic stroke, thereby facilitating the advancement of nanomedicine development. The review discusses the potential benefits and existing challenges associated with employing nanoparticles in the treatment of ischemic stroke, offering new perspectives on designing efficacious nanoparticles to enhance ischemic stroke treatment outcomes.

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Targeted pathophysiological treatment of ischemic stroke using nanoparticle-based drug delivery system

Abstract

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