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Abstract
Neurodegenerative disorders (NDs) are characterized by the accumulation of misfolded proteins and impaired cellular clearance mechanisms.
- Autophagy is crucial for maintaining protein balance and neuronal health.
- Dysregulation of autophagy is linked to the development of various neurodegenerative disorders.
- Bioactive compounds like flavonoids, alkaloids, polyphenols, and terpenoids may enhance autophagic activity.
- These compounds could promote the clearance of toxic proteins such as amyloid-β, tau, and α-synuclein.
- Strategies involving nanotechnology may improve the effectiveness and availability of these bioactive compounds.
- Pharmacological or natural induction of autophagy might alleviate neurodegenerative conditions, though specific modulation is necessary.
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