Full text is available at the source.
Targeting Autophagy with Bioactive Compounds: Therapeutic Potential in Neurodegenerative Disorders
Using natural compounds to boost cell cleanup for treating brain diseases
AI simplified
Abstract
Neurodegenerative disorders (NDs) are characterized by the accumulation of misfolded proteins and impaired cellular clearance mechanisms.
- Autophagy is crucial for maintaining protein balance and neuronal health.
- Dysregulation of autophagy is linked to the development of various neurodegenerative disorders.
- Bioactive compounds like flavonoids, alkaloids, polyphenols, and terpenoids may enhance autophagic activity.
- These compounds could promote the clearance of toxic proteins such as amyloid-β, tau, and α-synuclein.
- Strategies involving nanotechnology may improve the effectiveness and availability of these bioactive compounds.
- Pharmacological or natural induction of autophagy might alleviate neurodegenerative conditions, though specific modulation is necessary.
AI simplified