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Abstract
Microglia-driven neuroinflammation is identified as a key driver of neurodegenerative diseases such as Alzheimer's, Parkinson's, and amyotrophic lateral sclerosis.
- Mitochondrial dysfunction may trigger early microglial activation in neurodegenerative diseases.
- Conserved mechanisms regulating microglial activation include metabolic reprogramming, impaired removal of damaged mitochondria, and inflammatory signaling.
- Specific proteins like Aβ, α-synuclein, and TDP-43 engage these pathways through distinct molecular routes related to each disease.
- Therapeutic strategies targeting mitochondrial health in microglia, such as inhibitors and agonists, are primarily in preclinical stages.
- New potential targets like OLFML3 and GPNMB require further validation in microglial function.
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