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Abstract
Resistance to immunotherapy in colorectal cancer is linked to an immunosuppressive tumor microenvironment characterized by specific cellular senescence-related genes.
- Cancer-associated fibroblasts are identified as key regulators of the tumor microenvironment in colorectal cancer.
- Cellular senescence and the senescence-associated secretory phenotype may drive the activity of these fibroblasts.
- A prognostic signature based on differentially expressed cellular senescence-related genes was developed and validated in independent cohorts.
- Integrative analyses revealed associations between the prognostic signature and immune cell infiltration in colorectal cancer.
- Validation of findings at the protein level was conducted using techniques such as multiplex immunofluorescence.
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