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Targeting tau in Alzheimer’s and beyond: Insights into pathology and therapeutic strategies
Targeting tau protein in Alzheimer's and other diseases: Understanding its role in illness and treatment approaches
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Abstract
Tauopathies are a group of approximately 20 neurodegenerative diseases linked to tau protein accumulation in brain neurons.
- Hyperphosphorylated tau protein isoforms initiate the formation of neurofibrillary tangles, contributing to neuronal death.
- Tauopathies include Alzheimer's disease, Parkinson's disease, and frontotemporal dementia.
- Current tau biomarkers from imaging and bodily fluids aid in the evaluation and diagnosis of these diseases.
- Potential strategies to counteract tau aggregation include suppressing toxic tau formation and stabilizing microtubules.
- New therapeutic developments focus on preventing harmful changes to tau and designing targeted immunogens.
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