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Tau aggregation in the hippocampal formation: an ageing or a pathological process?
Tau build-up in the memory system: a sign of aging or disease?
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Abstract
Tauopathy in the hippocampal formation is age-related but not solely dependent on age or Alzheimer’s disease.
- Tauopathy affects the entorhinal and hippocampal regions in humans, contributing to cognitive decline.
- The relationship between tauopathy and cognitive impairment is complex and not fully understood.
- APP dysfunction appears to amplify tauopathy effects in the hippocampal formation.
- The findings suggest the potential for targeting tauopathy as a therapeutic strategy to delay Alzheimer's disease.
- There is a need for relevant animal models to further explore these findings.
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