How Tau Protein Affects Cell Structures and Links to Brain Diseases

Abnormal tau phosphorylation is associated with neuronal dysfunction and the formation of insoluble aggregates.

• Dysregulation of tau protein is linked to neurodegenerative diseases, particularly tauopathies.
• Therapeutic strategies may include reducing tau phosphorylation, inhibiting aggregation, and enhancing clearance through autophagy and immunotherapies.
• Preclinical models indicate that candidates like anle138b and methylene blue may show efficacy in targeting tau pathology.
• The relationship between tau protein and amyloid-beta pathology suggests a complex interplay that impacts therapeutic approaches.
• Understanding tau functions at cellular and subcellular levels is crucial for developing targeted treatments for tau-related neurotoxicity.

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