Frontiers in bioscience (Landmark edition)May 30, 2026

Tectorigenin Protects Blood Vessel Cells from Radiation Damage by Blocking Cell Cleanup through the PINK1/Parkin Pathway

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Updated May 31, 2026

Abstract

Tectorigenin significantly reduced radiation-induced oxidative stress and apoptosis in endothelial cells.

Irradiation was found to cause oxidative stress and apoptosis in endothelial cells.
Tectorigenin suppressed the generation of mitochondrial reactive oxygen species (ROS) and membrane depolarization.
The compound was associated with reduced activation of mitophagy through downregulation of PINK1 and Parkin expression.
Inhibition of PINK1 enhanced the protective effects of Tectorigenin, while PINK1 overexpression negated these benefits.

Simplified

OBJECTIVE: This study aimed to investigate the protective effect of Tectorigenin against irradiation-induced endothelial cell damage and to elucidate the underlying mechanism, thereby identifying potential therapeutic targets for irradiation-induced heart disease.

METHODS: Anradiation-induced injury model was established to evaluate oxidative stress and apoptosis. Mitochondrial morphology was assessed by transmission electron microscopy, while mitochondrial function was evaluated using JC-1 staining, MitoSOX staining, immunofluorescence, and ATP assays. To investigate the involvement of mitophagy in the underlying mechanism, a mitophagy inhibitor, PINK1 siRNA, and PINK1 overexpression were employed. in vitro

RESULTS: Tectorigenin significantly attenuated radiation-induced oxidative stress and apoptosis, suppressed mitochondrial reactive oxygen species (ROS) generation and membrane depolarization, and attenuated mitophagy activation through downregulation of PINK1 and Parkin expression. Notably, PINK1 inhibition potentiated these protective effects, whereas PINK1 overexpression abrogated Tec-mediated protection.

CONCLUSION: Tectorigenin alleviated irradiation-induced injury through suppressing the activation of PINK1-mediated mitophagy, thereby offering potential therapeutic targets and candidate agents for radiation-induced heart disease (RIHD).

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Tectorigenin Protects Blood Vessel Cells from Radiation Damage by Blocking Cell Cleanup through the PINK1/Parkin Pathway

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