Nucleus (Austin, Tex.)Sep 18, 2026

Structure and behavior of chromosome ends during cell division

Longevity & Aging Weekly Brief ↗PubMed ↗DOI ↗OA ↗

Updated Sep 19, 2026

Abstract

Telomeres may play a crucial role in proper chromosome segregation and chromatin organization during mitosis.

Telomeres are structured to protect chromosome ends and maintain genome stability.
Their dynamics during mitosis, involving cellular reorganization, remain incompletely understood.
Telomeric proteins TRF1 and TNKS1 have been observed to interact with centrosomes and spindle components.
Telomeres interface with chromatin and factors involved in nuclear membrane reassembly during late mitosis.
Defects in telomere interactions during mitosis can lead to dysfunction and genomic instability.
Understanding these dynamics is important for exploring aging and telomere-related diseases.

Simplified

Telomeres are specialized chromosomal structures that protect chromosome ends and maintain genome stability. Their organization depends on telomeric DNA repeats, the shelterin complex, accessory factors, and telomerase. While telomere structure and maintenance have been characterized, their dynamics during mammalian mitosis remain incompletely understood. Mitosis involves profound cellular reorganization, including chromatin condensation, spindle formation, and nuclear membrane disassembly and reassembly. Emerging evidence suggests that telomeres participate in these processes and may contribute to proper chromosome segregation and post-mitotic chromatin organization. Studies indicate that telomeric proteins such as TRF1 and TNKS1 interact with centrosomes and spindle components, while telomeres also interface with chromatin and nuclear membrane reassembly factors, including BAF1, LAP2α, and the ESCRT machinery during late mitosis. Defects in these processes or interactions can lead to telomere dysfunction and genomic instability. Understanding telomere dynamics during mitosis is therefore critical for elucidating mechanisms underlying aging, laminopathies, and other telomere-related human diseases.

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Structure and behavior of chromosome ends during cell division

Abstract

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