We can’t show the full text here under this license. Use the link below to read it at the source.
TFEB confers resistance against the chemotherapeutic agent CX-5461
TFEB helps cells resist the chemotherapy drug CX-5461
AI simplified
Abstract
Gemcitabine causes and promotes protective signals through transcription factor EB ().
- Gemcitabine disrupts DNA replication while also inducing nucleolar stress.
- The anticancer agent CX-5461, which is designed to induce nucleolar stress, leads to TFEB accumulating in the nucleus.
- Interfering with TFEB enhances the sensitivity of cancer cells to both CX-5461 and gemcitabine.
- TFEB is associated with providing protective responses against stress from chemotherapeutic drugs.
AI simplified
Key numbers
50%
Decrease in clonogenic growth ability
Observed in HeLa and MIA PaCa-2 cells with reduced levels.
60%
Clonogenic growth reduction at highest CX-5461 concentration
Measured in shTFEB cells compared to control at high CX-5461 doses.