Journal of diabetes investigationOct 29, 2026

The daily gene DBP controls muscle response to insulin and its daily changes

Circadian Biology Weekly Brief ↗PubMed ↗DOI ↗OA ↗

Updated Nov 2, 2026

Abstract

Systemic knockout of the D-box binding protein (DBP) gene was used to investigate its role in glucose metabolism.

Circadian rhythm disruption may be linked to metabolic disorders.
DBP is identified as a clock output gene that influences glucose metabolism.
The specific effects of DBP on glucose metabolism are not fully understood.

Simplified

Circadian rhythm disruption is associated with metabolic disorders, yet the role of clock genes in glucose metabolism remains unclear. D-box binding protein (DBP) is a clock output gene that activates the D-box, and we used systemic Dbp knockout (KO) mice to investigate DBP's role in glucose metabolism.

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