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Abstract
PGAM1 functions as a metabolic-autophagy checkpoint linking glycolysis to autophagy initiation.
- PGAM1 acts as a molecular scaffold that recruits a specific protein complex necessary for the formation of autophagosomes.
- This regulatory role of PGAM1 is essential for cellular survival and is conserved across species.
- The activity of PGAM1 in autophagy is independent of its role in glycolysis.
- PGAM1 is regulated by a specific phosphorylation process that enhances its interaction with other proteins during nutrient depletion.
- In cancer cells, higher levels of PGAM1 are associated with increased glycolysis and autophagy, contributing to tumor growth and resilience.
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