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The glymphatic system clears amyloid beta and tau from brain to plasma in humans
The brain’s cleaning system moves amyloid beta and tau proteins from the brain into the blood in humans
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Abstract
Glymphatic clearance during normal sleep increased morning plasma levels of Alzheimer's disease biomarkers in 39 participants.
- dysfunction may link sleep disruption to Alzheimer's disease.
- In animal studies, impairment of the glymphatic system can lead to Alzheimer's pathology.
- Participants experienced increased clearance of and during normal sleep compared to sleep deprivation.
- Monitoring revealed that reduced brain resistance supports the overnight clearance of Alzheimer's biomarkers.
- These findings suggest that enhancing glymphatic function could be a potential approach to slowing Alzheimer's disease progression.
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Key numbers
10.71 pg/mL
Increase in plasma Aβ levels
Difference in morning plasma Aβ levels under sleep condition.
39
Participants enrolled
Total number of healthy participants in the study.