The SCN Clock Governs Circadian Transcription Rhythms in Murine Epididymal White Adipose Tissue

Most rhythmic transcripts in adipose tissue were not rhythmic in mice lacking the SCN clock.

• The suprachiasmatic nucleus (SCN) is crucial for regulating circadian rhythms in peripheral tissues, including adipose tissue.
• In mice without the SCN clock, many rhythmic transcripts present in control animals were absent, while some transcripts gained rhythmicity.
• Core clock genes continued to show rhythmic patterns in both control and SCN-mutant mice, although their rhythms were dampened and phase advanced in mutants.
• The absence of the SCN clock led to a loss of rhythmic expression in metabolic pathway-related transcripts in adipose tissue.
• Transcripts that exhibited new rhythmic patterns in SCN-mutant mice were linked to various immune functions, suggesting a shift in regulatory mechanisms.

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