The SCN‐independent clocks, methamphetamine and food restriction

Nov 3, 2009The European journal of neuroscience

Body Clocks Outside the Main Brain Timer Influenced by Methamphetamine and Food Restriction

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Abstract

The central catecholaminergic system is probably involved in the expression of SCN-independent rhythms.

  • Mammals have a central clock in the hypothalamic suprachiasmatic nucleus (SCN) and peripheral clocks in various tissues.
  • Two SCN-independent clocks respond to nonphotic cues: one induced by methamphetamine and another by restricted feeding.
  • SCN-independent rhythms do not require canonical clock genes for expression.
  • Unique phenomena such as spontaneous internal desynchronization and nonphotic entrainment are observed in MAP-induced activity rhythms in rats and human sleep-wake cycles.
  • The SCN-independent clock may regulate behavior in response to nonphotic time cues and is related to arousal mechanisms.

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