The therapeutic potential of dietary intervention: based on the mechanism of a tryptophan derivative-indole propionic acid on metabolic disorders

Jan 8, 2024Critical reviews in food science and nutrition

Dietary treatment potential based on how indole propionic acid, a tryptophan byproduct, affects metabolic disorders

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Abstract

Tryptophan metabolites, particularly indole propionic acid (IPA), may affect host health and disease.

  • IPA can activate the immune system through specific receptors, influencing host and microbe interactions.
  • Different levels of IPA in the bloodstream may predict the risk of non-alcoholic fatty liver disease (NAFLD), type 2 diabetes mellitus (T2DM), and cardiovascular disease (CVD).
  • IPA is associated with the reduction of cognitive impairment caused by oxidative damage and gut inflammation.
  • It may help inhibit fat accumulation in the liver and improve symptoms of NAFLD.
  • IPA is suggested to enhance the intestinal barrier and support overall gut health.

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