Current drug targetsSep 18, 2025

Plant-Based Natural Products as Possible Treatments for Aging

Longevity & Aging Weekly Brief ↗PubMed ↗DOI ↗

Updated Jan 19, 2026

Abstract

Plant-derived compounds may target key pathways involved in aging, including Sirtuins (SIRT1) and AMP-activated protein kinase (AMPK).

Plant-based natural compounds have antioxidant, anti-inflammatory, and cellular repair properties.
These compounds may address oxidative stress, mitochondrial dysfunction, cellular senescence, and chronic inflammation.
Evidence suggests they could help prevent or delay age-related disorders, such as neurodegenerative diseases and cardiovascular conditions.
Challenges like low bioavailability and limited clinical validation exist for these compounds.
Advancements in drug delivery systems and comprehensive clinical trials are necessary to harness their full therapeutic potential.

Simplified

Aging is a complex biological process marked by progressive cellular and tissue decline, leading to an increased risk of age-related diseases. Plant-based natural compounds, including polyphenols, flavonoids, carotenoids, alkaloids, and terpenoids, have gained attention for their potential in mitigating aging-related damage through antioxidant, anti-inflammatory, and cellular repair mechanisms. The review identified that plant-derived bioactive compounds target key pathways involved in aging, including Sirtuins (SIRT1), AMP-activated protein kinase (AMPK), and Nuclear Factor-kappa B (NF-κB). These compounds address key hallmarks of aging, such as oxidative stress, mitochondrial dysfunction, cellular senescence, and chronic inflammation. Evidence suggests their potential in preventing or delaying age-related disorders, including neurodegenerative diseases, cardiovascular conditions, and skin aging. Plant-derived compounds offer a promising alternative to synthetic anti-aging interventions due to their efficacy, safety, and sustainability. However, challenges such as low bioavailability and limited clinical validation must be addressed. Advances in drug delivery systems and comprehensive clinical trials are critical to realizing their full therapeutic potential. Plant-based bioactive compounds represent a significant opportunity for developing safer and more sustainable anti-aging therapies. Continued research is essential to overcome existing limitations and facilitate the integration of these approaches into mainstream healthcare practices.

Plant-Based Natural Products as Possible Treatments for Aging

Abstract

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