Therapeutic Strategies Targeting the Kidney-Liver-Immune-Heart Network: Circadian and Mechanosensory Pathways in CKD-Associated Cardiac Injury.
Treatment Approaches for Kidney Disease-Related Heart Damage Involving Body Clock and Mechanical Sensing in Kidney, Liver, Immune, and Heart Systems
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Abstract
Vitamin A/retinoid metabolism may influence immune clock gene expression and promote pro-inflammatory monocyte states.
- Hepatic clock-dependent retinoid handling is associated with the stimulation of specific signaling pathways that may affect immune responses.
- Mechanosensory signaling integrates hemodynamic forces with tissue microenvironment cues.
- G protein-coupled receptor 68 could link mechanical and inflammatory signaling in chronic kidney disease-related cardiac injury.
- Potential therapeutic directions include circadian alignment, modulation of retinoid metabolism, and targeted inhibition of immune and mechanosensory effectors.
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