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Design, synthesis and molecular docking of thiazolidinedione based benzene sulphonamide derivatives containing pyrazole core as potential anti-diabetic agents
Design and testing of new chemical compounds with a pyrazole core to find potential anti-diabetic drugs
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Abstract
Compound 7p showed a 61.2% PPAR-γ transactivation, significantly improving blood glucose levels compared to standard drugs.
- Compound 7p was more effective in lowering blood glucose than pioglitazone and rosiglitazone.
- A 1.9-fold increase in gene expression was observed with compound 7p.
- Molecular docking studies revealed strong interactions between compound 7p and specific amino acids in the PPARγ target.
- No liver damage or significant weight gain was reported with compound 7p.
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