Three-Dimensional Bioprinting of Organoids: Past, Present, and Prospective

Jan 11, 2024Tissue engineering. Part A

3D Bioprinting of Mini-Organs: History, Current Advances, and Future Possibilities

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Regenerative Health on OpenScience ↗PubMed ↗DOI ↗

Abstract

3D bioprinting of organoids may enhance the efficiency of cell production for biomedical research.

Organoids are 3D tissue models derived from stem cells that mimic human organ structure and function.
Traditional organoid culture methods are time-consuming and produce low cell yields.
3D bioprinting uses bioinks with suspended cells and scaffolds to potentially improve organoid development.
A comparison of organoid-building techniques, particularly 3D bioprinting, could clarify their respective benefits.
The review discusses applications of 3D bioprinted organoids in tissue engineering, drug screening, and regenerative medicine.

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Organoids are three-dimensional (3D)tissue models that are derived from stem cells and can closely mimic the structure and function of human organs. The ability to create organoids that recapitulate the complex cellular architecture of organs has emerged as an innovative technique in biomedical research and drug development. However, traditional methods of organoid culture are time consuming and often yield low quantities of cells, which has led to the development of 3D bioprinting of organoids from bioinks containing suspended cells and desired scaffolds. A comparison across different organoid-building techniques, focusing on 3D bioprinting and its benefits, may be helpful and was yet to be distinguished. The goal of this review is to provide an overview of the current state of 3D bioprinting of organoids and its potential applications in tissue engineering, drug screening, and regenerative medicine. in vitro

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Three-Dimensional Bioprinting of Organoids: Past, Present, and Prospective

Abstract

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