[Construction of a three-level intervention framework in traditional Chinese medicine(TCM) chronomedicine and its application in precision treatment of gastrointestinal diseases].

No SJR dataJan 8, 2026Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

A three-level treatment plan based on traditional Chinese medicine timing to improve precise care for digestive diseases

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Circadian Biology on OpenScience ↗PubMed ↗DOI ↗

Abstract

A chrono-intervention framework utilizing Traditional Chinese Medicine theories offers significant clinical value for managing gastrointestinal diseases.

Gastrointestinal diseases show complex patterns that vary over time.
Circadian rhythms influence gastrointestinal functions, yet their clinical application is limited.
Traditional Chinese Medicine provides a model linking time to disease symptoms and treatment.
Proposed interventions include timing-based pharmacological administration and acupuncture techniques.
These time-adapted strategies may enhance diagnostic and therapeutic approaches for gastrointestinal issues.

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Gastrointestinal diseases, as globally prevalent disorders, exhibit complex pathogenesis with marked time-dependent characteristics. Although modern medical research has recognized the circadian rhythm of gastrointestinal functions, the clinical application of temporal factors remains insufficient. Traditional Chinese medicine(TCM) chronomedicine theories, including the midnight-noon and ebb-flow doctrine, Yin and Yang of four seasons, and five movements and six Qi, reveal a "time-syndrome-pathology" correlation model that provides unique perspectives and methods for the prevention and treatment of gastrointestinal diseases. This study proposed a chrono-intervention framework that incorporated diurnal, seasonal, and annual rhythmic patterns through methods such as time-adapted pharmacological administration, time-adopted acupuncture, and time-adapted specific acupoint application. The results indicate that TCM chronomedicine theories offer "time-adapted" diagnostic and therapeutic strategies for gastrointestinal diseases, demonstrating significant clinical value. These strategies provide a new paradigm for precision medicine, promote the modernization of TCM theoretical interpretation, and lay a scientific foundation for the internationalization of TCM.