Thrombospondin-1, a Stretch-Sensitive Protein, May Cause Aging in Support Cells Linked to Pelvic Organ Prolapse

Thrombospondin-1 (THBS1) may activate a cellular senescence-matrix degradation axis in response to stress injury.

• Pelvic organ prolapse (POP) management traditionally focuses on repairing anatomy rather than addressing underlying tissue issues.
• Fibroblast dysfunction is linked to the degeneration of pelvic tissues.
• The regulation of fibroblast dysfunction in pelvic tissue remains poorly understood.
• THBS1 may serve as a pro-senescent protein involved in the degeneration of pelvic tissues.

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