Time-restricted feeding protects the blood pressure circadian rhythm in diabetic mice

Jun 23, 2021Proceedings of the National Academy of Sciences of the United States of America

Limited daily feeding helps maintain normal daily blood pressure patterns in diabetic mice

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Abstract

Time-restricted feeding (TRF) for 8 hours daily prevented nondipping blood pressure in diabetic mice.

Diabetic mice exhibited arrhythmic food intake and blood pressure patterns on a normal chow diet.
Implementing TRF restored the disrupted blood pressure circadian rhythm in diabetic mice.
Extending food availability from 8 hours to 12 hours while maintaining isocaloric intake still protected the blood pressure rhythm.
TRF did not affect blood pressure dipping in wild-type mice.
TRF may protect the blood pressure circadian rhythm by reducing sympathetic activity during the light phase.

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The quantity and quality of food intake have been considered crucial for peoples' wellness. Only recently has it become appreciated that the timing of food intake is also critical. Nondipping blood pressure (BP) is prevalent in diabetic patients and is associated with increased cardiovascular events. However, the causes and mechanisms of nondipping BP in diabetes are not fully understood. Here, we report that food intake and BP were arrhythmic in diabeticmice fed a normal chow diet ad libitum. Imposing a food intake diurnal rhythm by time-restricted feeding (TRF; food was only available for 8 h during the active phase) preventedmice from developing nondipping BP and effectively restored the already disrupted BP circadian rhythm inmice. Interestingly, increasing the time of food availability from 8 h to 12 h during the active dark phase inmice prompted isocaloric feeding and still provided robust protection of the BP circadian rhythm inmice. In contrast, neither 8-h nor 12-h TRF affected BP dipping in wild-type mice. Mechanistically, we demonstrate that TRF protects the BP circadian rhythm inmice via suppressing the sympathetic activity during the light phase when they are inactive and fasting. Collectively, these data reveal a potentially pivotal role of the timing of food intake in the prevention and treatment of nondipping BP in diabetes. db/db db/db db/db db/db db/db db/db

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Time-restricted feeding protects the blood pressure circadian rhythm in diabetic mice

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