Time-limited eating improves health in both male and female mice and increases lifespan in males

Nightly time-restricted feeding improved healthspan in male and female mice, but extended lifespan only in males on the 8-hour schedule.

This long-term mouse study in 264 male and 264 female C57BL/6J mice fed regular chow found that 12-hour and 8-hour nightly feeding windows improved rhythmicity, body composition, frailty, and disease onset, with a 12% median lifespan extension only in males under 8-hour TRF.

These are mouse results, and the strongest effects occurred in the 8-hour group that also voluntarily ate fewer calories, making the specific contribution of time restriction harder to isolate.