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Rhythmic Expression of timeless : A Basis for Promoting Circadian Cycles in period Gene Autoregulation
Rhythmic activity of timeless helps regulate daily cycles in period gene control
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Abstract
The clock gene timeless (tim) is required for circadian rhythmicity in Drosophila.
- tim RNA levels follow a circadian rhythm.
- The rhythm of tim RNA accumulation matches the previously reported phase and period of per.
- tim RNA oscillations depend on the presence of PER and TIM proteins.
- The cyclic expression of tim may control the timing of PER protein accumulation and its movement into the nucleus.
- tim could promote circadian rhythms of per and tim transcription by timing their RNA and protein accumulation.
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