Current problems in cardiology

How tirzepatide works in heart failure patients who don’t have diabetes

Updated

Abstract

In a cohort of 897 patients, untreated individuals had a 3.12-fold higher risk of acute heart failure compared to those treated with tirzepatide.

  • Tirzepatide is associated with a significantly reduced risk of incident acute heart failure.
  • Patients not treated with tirzepatide showed a 3.57-fold higher risk of major adverse cardiovascular events.
  • The risk of stroke was 2.796 times greater in untreated patients compared to those receiving tirzepatide.
  • Chronic kidney disease and coronary arterial disease risks were also higher in the untreated group, with hazard ratios of 1.48 and 1.474, respectively.

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Funding

Competing interests

Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Wai Hong Wilson Tang, MD reports financial support was provided by National Institutes of Health. Wai Hong Wilson Tang, MD reports a relationship with Cardiol Therapeutics Inc that includes: consulting or advisory. Wai Hong Wilson Tang, MD reports a relationship with Genomics plc that includes: consulting or advisory. Wai Hong Wilson Tang, MD reports a relationship with Zehna Therapeutics that includes: consulting or advisory. Wai Hong Wilson Tang, MD reports a relationship with Boston Scientific that includes: consulting or advisory. Wai Hong Wilson Tang, MD reports a relationship with WhiteSwell, Inc that includes: consulting or advisory. Wai Hong Wilson Tang, MD reports a relationship with CardiaTec Biosciences that includes: consulting or advisory. Wai Hong Wilson Tang, MD reports a relationship with Bristol-Myers Squibb, Inc that includes: consulting or advisory. Wai Hong Wilson Tang, MD reports a relationship with Alleviant Medical, Inc that includes: consulting or advisory. Wai Hong Wilson Tang, MD reports a relationship with Alexion Pharmaceuticals, Inc that includes: consulting or advisory. Wai Hong Wilson Tang, MD reports a relationship with Salubris Biotherapeutics, Inc that includes: consulting or advisory. Wai Hong Wilson Tang, MD reports a relationship with BioCardia, Inc that includes: consulting or advisory. Wai Hong Wilson Tang, MD reports a relationship with Springer Nature that includes: funding grants. Wai Hong Wilson Tang, MD reports a relationship with Belvoir Media Group that includes: funding grants. Wai Hong Wilson Tang, MD reports a relationship with American Board of Internal Medicine that includes: consulting or advisory and travel reimbursement.
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