Cell metabolism

Tirzepatide does not change metabolism adjustment in obesity but increases fat burning

Updated

Abstract

Tirzepatide promoted significant body weight reduction in phase 3 clinical trials.

  • In calorie-restricted, obese mice, chronic tirzepatide treatment reduced the drop in energy expenditure compared to vehicle-treated and pair-fed mice.
  • Tirzepatide treatment was associated with increased fat oxidation as indicated by a decrease in the respiratory exchange ratio in mice.
  • In a phase 1 clinical trial, tirzepatide led to increased fat oxidation and reductions in appetite and calorie intake during an ad libitum test meal compared to placebo.
  • Chronic treatment with tirzepatide did not appear to impact metabolic adaptation in the clinical trial.

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Funding

Competing interests

Declaration of interests L.S.O., W.C.R., H.-R.Q., J.L., H.N., A.H., E.J.P., S.U., Z.M., and T.C. are employees and shareholders of Eli Lilly and Company. E.R. has received grants or contracts from Amazon, Eli Lilly and Company, ICON, Novartis, and Sanofi; has received consulting fees from Altimmune, Amway (Nutrilite Health), Eli Lilly and Company, Energesis Pharmaceuticals, Generian, Kintai Therapeutics, Merck, Novo Nordisk, and YSOPIA Bioscience (LNC Therapeutics); has received honoraria from National Institutes of Health (NORC Review) and Open Academy of Medicine; and has received support for attending meetings from Aegean Conference on Precision Nutrition, American Association of Clinical Endocrinology, Clermont Auvergne University, Eli Lilly and Company Obesity Working Group, Frontiers in Obesity, Diabetes, and Metabolism Seminar, Les Journées Françaises de Nutrition, Lipedema Foundation Retreat, National Institutes of Health (NORC Review), New York University Grand Rounds, The Obesity Society, Quebec Society of Lipidology, Nutrition and Metabolism, RACMEM, Société Francophone du Diabète, and Tulane Personalized Health Institute. G.S.-D. has received support for attending meetings and travel from Eli Lilly and Company. C.K.M. serves on advisory boards for EHE Health and Wondr Health; receives compensation to facilitate continuing education events for Commission on Dietetic Registration; receives royalties from ABGIL (paid to his institution); receives research support from Eli Lilly and Company, Foundation for Food & Agriculture Research, Henry M. Jackson Foundation for the Advancement of Military Medicine, Leona M. and Harry B. Helmsley Charitable Trust, National Institute for Health and Care Research, National Institutes of Health National Science Foundation, State of Louisiana Federal American Rescue Plan, United States Department of Agriculture, and WW International; and receives honoraria and/or travel reimbursement for giving presentations and other academic activities from Bray Course Planning Committee, Brigham Young University, Duke University, Indiana University Bloomington, University of Alabama at Birmingham, University of Kansas Medical Center, and University of Nebraska-Lincoln. F.L.G. has received grants or contracts from Eli Lilly and Company; has received consulting fees from Altimmune, Dexcom, Basic Research, and NovMetaPharma; has received support for attending meetings and/or travel from Biohaven; and has stock or stock options in Pep-10, Slim Health Nutrition Inc., Rejuvenate Bio, Energesis Pharmaceuticals, Ketogenic Health System, GATC Health, and Uplifting Results Labs Inc.
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