Tissue Engineering Applications of Three-Dimensional Bioprinting

Feb 10, 2015Cell biochemistry and biophysics

Using 3D Bioprinting for Growing Replacement Tissues

AI simplified

Regenerative Health on OpenScience ↗PubMed ↗DOI ↗

Abstract

3D bioprinting technology enables the creation of complex living tissues using various biocompatible materials and cell types.

This technology allows for the simultaneous printing of different cell types in specific spatial arrangements.
Challenges remain in replicating the intricate structures and microarchitecture of native organs and tissues.
An integrated approach combining engineering, biomaterials, cell biology, physics, and medicine is necessary to enhance the effectiveness of 3D bioprinting.
Utilizing imaging techniques like MRI and CT scans, along with computer-aided design, aids in creating biomimetic tissue structures.
Current biomaterials used in 3D bioprinting may lack optimal viscosity, impacting the mechanical strength and integrity of the constructs.
A deeper understanding of the tissue and organ microenvironment is crucial for advancing 3D bioprinting capabilities.

AI simplified

Recent advances in tissue engineering have adapted the additive manufacturing technology, also known as three-dimensional printing, which is used in several industrial applications, for the fabrication of bioscaffolds and viable tissue and/or organs to overcome the limitations of other in vitro conventional methods. 3D bioprinting technology has gained enormous attention as it enabled 3D printing of a multitude of biocompatible materials, different types of cells and other supporting growth factors into complex functional living tissues in a 3D format. A major advantage of this technology is its ability for simultaneously 3D printing various cell types in defined spatial locations, which makes this technology applicable to regenerative medicine to meet the need for suitable for transplantation suitable organs and tissues. 3D bioprinting is yet to successfully overcome the many challenges related to building 3D structures that closely resemble native organs and tissues, which are complex structures with defined microarchitecture and a variety of cell types in a confined area. An integrated approach with a combination of technologies from the fields of engineering, biomaterials science, cell biology, physics, and medicine is required to address these complexities. Meeting this challenge is being made possible by directing the 3D bioprinting to manufacture biomimetic-shaped 3D structures, using organ/tissue images, obtained from magnetic resonance imaging and computerized tomography, and employing computer-aided design and manufacturing technologies. Applications of 3D bioprinting include the generation of multilayered skin, bone, vascular grafts, heart valves, etc. The current 3D bioprinting technologies need to be improved with respect to the mechanical strength and integrity in the manufactured constructs as the presently used biomaterials are not of optimal viscosity. A better understanding of the tissue/organ microenvironment, which consists of multiple types of cells, is imperative for successful 3D bioprinting.

Full Text

Full text is available at the source.

View full text (PDF) ↗View full text (HTML) ↗View full text ↗

Tissue Engineering Applications of Three-Dimensional Bioprinting

Abstract

Full Text

You found one interesting study. We’ll send the next 7.

what lands in your inbox each week:

Abstract

Full Text

Related papers

You found one interesting study. We’ll send the next 7.

what lands in your inbox each week: