TMAO’s Role in Gut-Brain Communication: How Microbiome Chemicals May Link Inflammation in the Brain to Thinking Problems

TMAO may be linked to neuroinflammation and cognitive dysfunction.

• TMAO is produced in the liver from trimethylamine, a compound derived from gut bacteria.
• Increasing evidence suggests a connection between TMAO and neurological disorders via the gut-brain axis.
• Potential mechanisms include neuroinflammation, oxidative stress, and activation of inflammatory pathways.
• TMAO and its precursors could serve as therapeutic targets for neurodegenerative disorders.
• There is a need for large, well-designed randomized clinical studies to clarify TMAO's therapeutic relevance.

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