The Journal of the American Academy of Orthopaedic Surgeons

Antibiotic Allergies Raise the Risk of Problems After Total Shoulder Replacement Surgery

Updated

Abstract

Of the 85,606 patients undergoing total shoulder arthroplasty, 9.15% reported an antibiotic allergy.

  • Patients with reported antibiotic allergies were younger and predominantly female compared to those without allergies.
  • Multivariate analysis indicated a higher likelihood of periprosthetic joint infection within 30 days, 1 year, and 2 years for patients with antibiotic allergies.
  • Increased rates of postoperative anemia, blood transfusion, and readmission within 90 days were associated with patients who reported antibiotic allergies.
  • Patients with a penicillin allergy had a significantly higher incidence of surgical revision due to periprosthetic joint infection.
  • The proportion of patients reporting antibiotic allergies increased from 8.60% in 2010 to 10.91% in 2018.

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Funding

Competing interests

Best or an immediate family member has received educational support from Arthrex, Smith and Nephew, and Stryker outside the submitted work. Srikumaran or an immediate family member has received grants and personal fees from Arthrex, grants and personal fees from Depuy, personal fees from Fx Shoulder, personal fees from Orthofix, other from Quantum OPS, other from ROM3, grants from Smith and Nephew, other from Sonogen, personal fees from Stryker, personal fees from Thieme, personal fees and other from Tigon Medical, grants and personal fees from Wright Medical Technology, outside the submitted work; has received a patent Conventus pending, a patent Fx Shoulder pending, and a patent Tigon Medical issued. The other authors certify that he or she has no commercial associations (eg, consultancies, stock ownership, equity interest, patent/licensing arrangements, etc.) that might pose a conflict of interest in connection with the submitted article. None of the following authors or any immediate family member has received anything of value from or has stock or stock options held in a commercial company or institution related directly or indirectly to the subject of this article: Bahoravitch, Jami, Nayar, Agarwal, and Kreulen.
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