How gene activity controls cell cleanup: processes, timing, and drug effects

Transcription factors, particularly TFEB, play a crucial role in regulating autophagy-related gene expression.

• Transcription factors are vital for maintaining cellular balance by controlling the expression of autophagy genes.
• TFEB is a key factor that translates upstream signals into specific genetic responses through various mechanisms.
• Dysregulation of transcription factor activity is linked to metabolic diseases and cancer.
• Direct targeting of transcription factors is emerging as a novel approach in pharmaceutical development.
• Current small molecules aimed at these transcription factors are being evaluated for their effectiveness in treating various diseases.

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