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Abstract
Thirty-one transcriptional regulators of microglial activation states were identified through CRISPR interference screens.
- Microglia can exhibit diverse activation states that are important for brain health and disease.
- Dysregulated microglial activation is associated with various brain disorders.
- Inhibiting specific regulators may affect microglial functions like interferon response and lysosomal activity.
- Certain knockdowns led to increased disease-associated signatures and enhanced phagocytosis.
- Widespread loss of methylation was observed with specific knockdowns, which may activate negative regulators of interferon signaling.
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