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Abstract
Senescent cells, which accumulate during aging, are a leading cause of aging-related decline.
- Senolytics can improve aging outcomes in both humans and mice by eliminating senescent cells.
- The effectiveness of senolytics varies among different cell types, indicating differences in cellular senescence.
- Factors inducing cellular senescence and the rate of senescent cell accumulation differ across organs.
- Current methods struggle to distinguish senescent cells from other cell types, necessitating the search for common markers.
- Recent advances in single-cell RNA sequencing have enabled the identification of novel senescent cells lacking established markers.
- Limited throughput of single-cell RNA sequencing technology highlights the need for improved methods to study rare senescent cells.
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