Translophagy: A possible connection between cell recycling problems and protein-making errors

Autophagy impairment increased translational errors, particularly during oxidative stress.

• Proteomic analysis identified ribosomal proteins and RNA-binding factors as potential autophagy cargo.
• Translational machinery components were found to localize to autophagic structures in human brain tissue affected by neurodegeneration.
• The findings suggest that autophagy may play a role in maintaining the quality of protein synthesis.
• The proposed mechanism, termed translophagy, could connect autophagy dysfunction with oxidative stress and protein abnormalities in neurodegenerative diseases.

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