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Abstract
Elevated risk of developing Alzheimer's disease is associated with hypomorphic variants of TREM2.
- Microglia in Alzheimer's patients with TREM2 risk variants exhibit an abundance of autophagic vesicles.
- TREM2-deficient mice with Alzheimer's-like pathology also show increased autophagic vesicles.
- Defective signaling through the mammalian target of rapamycin (mTOR) is linked to abnormal autophagy and affects energy levels.
- Restoration of metabolic function and autophagy in vitro was achieved using Dectin-1 and cyclocreatine.
- Dietary cyclocreatine reduced autophagy and improved microglial clustering and neuronal health in TREM2-deficient mice.
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