We canβt show the full text here under this license. Use the link below to read it at the source.
Association between triglyceride-glucose (TyG) related indices and cardiovascular diseases and mortality among individuals with metabolic dysfunction-associated steatotic liver disease: a cohort study of UK Biobank
Links between blood fat-sugar markers and heart disease or death in people with fatty liver disease related to metabolism
AI simplified
Abstract
In a cohort of 97,331 patients with (MASLD), those in the highest quartile of triglyceride-glucose () indices had a significantly increased risk of cardiovascular disease (CVD) and mortality.
- Participants with MASLD in the highest quartile of TyG had a hazard ratio of 1.19 for overall CVD compared to the lowest quartile.
- The risk of coronary heart disease (CHD) increased with higher TyG indices, with a hazard ratio of 1.35 for TyG-BMI in the fourth quartile.
- There was a nonlinear association of TyG with CVD outcomes, while TyG-BMI, TyG-waist circumference (WC), and TyG-waist-to-height ratio (WHtR) showed linear trends.
- TyG-WC and TyG-WHtR demonstrated superior predictive performance for CVD and mortality risk in MASLD patients, as indicated by higher C-index, net reclassification index (NRI), and integrated discrimination improvement index (IDI).
- The findings suggest that TyG-related indices may be effective surrogate predictors of CVD and mortality in individuals with MASLD.
AI simplified
Key numbers
1.19β1.39Γ
Increased Risk of Overall CVD
Compared to the lowest quartile of -related indices.
13β17%
Higher Risk of All-Cause Mortality
For each 1-standard deviation increment in these indices.
23β25%
Higher Risk of Cardiovascular Mortality
For each 1-standard deviation increment in -BMI, -WC, and -WHtR.