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Links between blood fat-sugar markers and heart disease or death in people with fatty liver disease related to metabolism
Updated
Abstract
In a cohort of 97,331 patients with (MASLD), those in the highest quartile of triglyceride-glucose () indices had a significantly increased risk of cardiovascular disease (CVD) and mortality.
- Participants with MASLD in the highest quartile of TyG had a hazard ratio of 1.19 for overall CVD compared to the lowest quartile.
- The risk of coronary heart disease (CHD) increased with higher TyG indices, with a hazard ratio of 1.35 for TyG-BMI in the fourth quartile.
- There was a nonlinear association of TyG with CVD outcomes, while TyG-BMI, TyG-waist circumference (WC), and TyG-waist-to-height ratio (WHtR) showed linear trends.
- TyG-WC and TyG-WHtR demonstrated superior predictive performance for CVD and mortality risk in MASLD patients, as indicated by higher C-index, net reclassification index (NRI), and integrated discrimination improvement index (IDI).
- The findings suggest that TyG-related indices may be effective surrogate predictors of CVD and mortality in individuals with MASLD.
Simplified
Key numbers
1.19–1.39×
Increased Risk of Overall CVD
Compared to the lowest quartile of -related indices.
13–17%
Higher Risk of All-Cause Mortality
For each 1-standard deviation increment in these indices.
23–25%
Higher Risk of Cardiovascular Mortality
For each 1-standard deviation increment in -BMI, -WC, and -WHtR.