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TRIM39-mediated deubiquitination upregulates RNF168 to evade autophagy-ferroptosis in triple-negative breast cancer
How TRIM39 helps triple-negative breast cancer avoid cell death by increasing RNF168
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Abstract
High expression of TRIM39 in triple-negative breast cancer cells is associated with resistance to .
- TRIM39-RNF168 ubiquitination axis is identified in triple-negative breast cancer cells.
- Excessive may lead to iron accumulation, contributing to ferroptosis.
- Knocking down TRIM39 or RNF168 can activate autophagy-linked ferroptosis.
- Activation of this pathway effectively suppresses tumor progression in living models.
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Key numbers
significantly reduced
Decrease in Cell Viability
Cell viability of cells after knockdown
higher ROS levels
Increased Markers
Reactive oxygen species (ROS) levels in knockdown cells