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Abstract
Essence
An ancestral trimer spike mRNA-LNP vaccine protected mice, sows' offspring, and actively immunized piglets against SADS-CoV challenge.
Evidence
This preclinical vaccine study designed a phylogenetic ancestral spike antigen and tested mRNA-LNP immunization in mice, sows and F1 offspring, piglets, and human, monkey-derived, and chicken cells.
Caveat
Protection was shown in animal challenge and cell assays, with antibody efficacy tracked for 140 days, not in human infection or longer-term outcomes.
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