Among 134 patients at high risk of cardiovascular events, 49% were identified as having high fasting plasma levels (≥ 3.8 μM).
Fasting plasma TMAO levels are linked to increased cardiovascular disease risk.
The median TMAO level in the cohort was 3.81 μM, with a range from 2.89 to 5.50 μM.
After a median follow-up of 58.8 months, the had a 2.88-fold increased mortality risk.
Adjustment for traditional cardiovascular risk factors did not eliminate the association of high TMAO levels with 5-year all-cause mortality.
An adjusted hazard ratio of 2.73 indicates that high TMAO levels are predictive of mortality risk.
Simplified
The gut microbiota metabolite (TMAO)-derived from dietary phosphatidylcholine-is mechanistically linked to cardiovascular disease (CVD) and increased cardiovascular risk. This study examined the relationship between fasting plasma TMAO levels and 5-year all-cause mortality in a cohort of patients at high risk of cardiovascular events (CORE-Thailand Registry). Of the 134 patients, 123 (92%) had established cardiovascular disease, and 11 (8%) had multiple risk factors. Fasting plasma TMAO levels were measured using nuclear magnetic resonance spectroscopy. Within this prospective cohort study, the median TMAO was 3.81 μM [interquartile range (IQR) 2.89-5.50 μM], with a mean age of 65 ± 11 years; 61% were men, and 39.6% had type II diabetes. Among 134 patients, 65 (49%) were identified as the (≥ 3.8 μM), and 69 (51%) were identified as the low-TMAO group (< 3.8 μM). After a median follow-up of 58.8 months, the high-TMAO group was associated with a 2.88-fold increased mortality risk. Following adjustment for traditional risk factors, high-sensitivity cardiac troponin-T, estimated glomerular filtration rate, angiotensin-converting enzyme (ACEI), or angiotensin-receptor blocker (ARB) use, the high-TMAO group remained predictive of 5-year all-cause mortality risk (the high-TMAO vs. the low-TMAO group, adjusted hazard ratio 2.73, 95% CI 1.13-6.54; P = 0.025). Among Thai patients at high risk of cardiovascular events, increased plasma TMAO levels portended greater long-term mortality risk.
Key numbers
2.88×
Increase in Mortality Risk
vs. low- group mortality risk comparison.
33 of 134
Deaths in Study Cohort
Total deaths during a median follow-up of 58.8 months.
3.81 μM
Median Level
Median fasting plasma level in the cohort.
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