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Gut bacteria-related chemical trimethylamine-N-oxide linked to 5-year death risk in Thai adults
Updated
Abstract
Among 134 patients at high risk of cardiovascular events, 49% were identified as having high fasting plasma levels (≥ 3.8 μM).
- Fasting plasma TMAO levels are linked to increased cardiovascular disease risk.
- The median TMAO level in the cohort was 3.81 μM, with a range from 2.89 to 5.50 μM.
- After a median follow-up of 58.8 months, the had a 2.88-fold increased mortality risk.
- Adjustment for traditional cardiovascular risk factors did not eliminate the association of high TMAO levels with 5-year all-cause mortality.
- An adjusted hazard ratio of 2.73 indicates that high TMAO levels are predictive of mortality risk.
Simplified
Key numbers
2.88×
Increase in Mortality Risk
vs. low- group mortality risk comparison.
33 of 134
Deaths in Study Cohort
Total deaths during a median follow-up of 58.8 months.
3.81 μM
Median Level
Median fasting plasma level in the cohort.