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Trimethylamine N-oxide levels and heart health outcomes in chronic heart failure patients after heart attack
Updated
Abstract
In a cohort of 1208 patients with chronic heart failure after myocardial infarction, elevated levels were associated with a hazard ratio of 2.31 for .
- TMAO levels were higher in older patients with histories of atrial fibrillation and diabetes.
- Cox regression analysis indicated a significant predictive value of TMAO for major adverse cardiac events (MACE) after adjusting for traditional risk factors.
- The risk of MACE increased with higher TMAO levels, particularly when levels exceeded the median.
- TMAO was also identified as an independent predictor of all-cause mortality with a hazard ratio of 2.15 after adjustment for conventional risk factors.
Simplified
Key numbers
2.31
Hazard Ratio for
Adjusted for traditional risk factors in CHF patients after MI
12.6%
Integrated Discrimination Improvement (IDI)
Enhancement in risk prediction accuracy
2.15
Hazard Ratio for All-Cause Mortality
Adjusted for conventional risk factors