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Trimethylamine-N-oxide (TMAO) predicts short- and long-term mortality and poor neurological outcome in out-of-hospital cardiac arrest patients
Trimethylamine-N-oxide (TMAO) levels predict short- and long-term survival and brain recovery after cardiac arrest outside the hospital
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Abstract
In a cohort of 258 out-of-hospital cardiac arrest patients, 44.6% died during hospitalization.
- Higher admission TMAO levels were observed in patients who did not survive hospitalization compared to survivors.
- The median TMAO level for non-survivors was 13.2 μmol L-1, while it was 6.4 μmol L-1 for survivors.
- TMAO levels were significantly associated with in-hospital mortality, with an adjusted odds ratio of 2.1.
- Similar associations were found for 90-day mortality and neurological outcomes in univariate analyses.
- TMAO levels may help improve prognostication for patients after out-of-hospital cardiac arrest.
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