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Interaction between two brain receptors may explain how ketamine changes synapse adaptability
Updated
Abstract
Essence
Ketamine appears to use coordinated TrkB and mGluR5 signaling and trafficking to shift synaptic plasticity.
Evidence
Mechanistic synaptic-plasticity study examined TrkB/mGluR5 cross-talk, BDNF signaling, receptor trafficking, ketamine, and an mGluR5 positive allosteric modulator.
Caveat
The abstract does not specify the experimental model or clinical testing, so therapeutic relevance rests on mechanistic evidence.
Simplified
Psychedelic Science