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Tryptophan Metabolism: A Link Between the Gut Microbiota and Brain
How Gut Bacteria and Brain Are Connected Through Tryptophan Breakdown
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Abstract
Tryptophan is the sole precursor of serotonin, a key neurotransmitter involved in brain and gut functions.
- Tryptophan contributes to the normal growth and health of both animals and humans.
- It plays a modulatory role in the gut-brain axis, affecting both central neurotransmission and intestinal functions.
- Tryptophan can be metabolized into kynurenine, tryptamine, and indole, influencing neuroendocrine and immune responses in the gut.
- The gut microbiota significantly influences tryptophan metabolism, potentially affecting brain function.
- Recent advances show how gut microbes modulate tryptophan metabolism and its impact on brain activities.
- Modulating intestinal tryptophan metabolism may offer therapeutic options for addressing brain and gastrointestinal disorders.
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