Tuberculosis Prognosis and Clinical Synergistic Activity with gut Microbiome

Feb 19, 2026Indian journal of microbiology

Tuberculosis outcomes linked to interactions with gut bacteria

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Abstract

A significant association exists between gut microbiota and tuberculosis, which is a leading cause of global mortality.

Tuberculosis may lead to an imbalance in gut microbiota, known as gut microbial dysbiosis.
This dysbiosis is characterized by changes in the abundance of specific microbes, particularly those that produce short-chain fatty acids.
There may be interactions between the gut microbiome and the brain, liver, and lungs, potentially affecting these organs.
Alterations in gut microbiota often occur with the use of antimycobacterial drugs.
The review highlights the importance of gut commensal bacteria in developing clinical strategies for tuberculosis treatment.

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The association between tuberculosis and gut microbiota is notable clinical synergistic action. Tuberculosis is a highly contagious illness that poses a huge global risk., an acid-fast bacillus, is responsible for one of the top ten death associated lethal infection. The study of human commensal bacteria has a strong link to tuberculosis and its treatment. The gut microbiota is frequently altered with antimycobacterial drugs. Importantly, there was a significant association found between the gut microbiome and the brain via the gut-brain axis. This interaction is also thought to exist along the gut-liver and gut-lung axis, with possible connections to appropriate organs as well.make up the majority of the microbiota in mammals' guts. Crucially, substantial data from human and animal studies shows that mycobacterial infection causes an imbalance in the gut microbiota, known as gut microbial dysbiosis. This dysbiosis is distinguished by variations in the abundance of certain microbes, particularly those that produce short-chain fatty acids (SCFAs), such asand. The review examined various studies on the association between tuberculosis and gut microbiota in order to develop a clinical algorithm and potential immune regulation against tuberculosis employing crucial gut commensal bacteria. Mycobacterium tuberculosis Bacteroidetes, Firmicutes, Proteobacteria, Actinobacteria, Verrucomicrobia, and Fusobacteria Bifidobacterium Ruminococcus

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Tuberculosis Prognosis and Clinical Synergistic Activity with gut Microbiome

Abstract

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