Remodeling of tumor microenvironment by cellular senescence and immunosenescence in cervical cancer

Cervical cancer in women aged 65 and older is often diagnosed at a more advanced stage with poorer prognosis.

• Cellular senescence is characterized by stable cell cycle arrest and metabolic reprogramming.
• In the immune system, senescence is referred to as immunosenescence.
• Senescent cells in cervical cancer can prevent tumor initiation but may also promote tumor development and resistance to treatment.
• The tumor microenvironment in elderly patients requires further exploration to understand the role of senescent cells.
• Senotherapeutics may help eliminate senescent cells and enhance antitumor immunity.

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