Tunicate cellulose nanocrystals strengthened injectable stretchable hydrogel as multi-responsive enhanced antibacterial wound dressing for promoting diabetic wound healing

Aug 22, 2024Carbohydrate polymers

Injectable stretchable hydrogel strengthened with tunicate cellulose nanocrystals as a multi-responsive antibacterial dressing to help heal diabetic wounds

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Regenerative Health on OpenScience ↗PubMed ↗DOI ↗

Abstract

An injectable multifunctional hydrogel demonstrated significant improvements in diabetic wound healing compared to commercial dressings.

The hydrogel is responsive to pH, temperature, and glucose due to dynamic covalent cross-linking.
It can incorporate insulin for on-demand drug release, adapting to the variable wound environment.
Key properties evaluated include self-healing, mechanical strength, antibacterial effects, and biocompatibility.
The addition of photothermal particles enhances antibacterial activity and adhesion while providing oxidation resistance.
The hydrogel showed superior healing effects in full-layer skin defect models compared to Tegaderm™.

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The intricate microenvironment of diabetic wounds characterized by hyperglycemia, intense oxidative stress, persistent bacterial infection and complex pH fluctuations hinders the healing process. Herein, an injectable multifunctional hydrogel (QPT) was developed, which exhibited excellent mechanical performance and triple responsiveness to pH, temperature, and glucose due to dynamic covalent cross-linking involving dynamic Schiff base bonds and phenylboronate esters with phenylboronic-modified quaternized chitosan (QCS-PBA), polydopamine coated tunicate cellulose crystals (PDA@TCNCs) and polyvinyl alcohol (PVA). Furthermore, the hydrogels can incorporate insulin (INS) drugs to adapt to the complex and variable wound environment in diabetic patients for on-demand drug release that promote diabetic wound healing. Based on various excellent properties of the colloidal materials, the hydrogels were evaluated for self-healing, rheological and mechanical properties, in vitro insulin response to pH/temperature/glucose release, antibacterial, antioxidant, tissue adhesion, coagulation, hemostasis in vivo and in vitro, and biocompatibility and biodegradability. By introducing PDA@TCNCs particles, the hydrogel has photothermal antibacterial activity, enhanced adhesion and oxidation resistance. We further demonstrated that these hydrogel dressings significantly improved the healing process compared to commercial dressings (Tegaderm™) in full-layer skin defect models. All indicated that the glucose-responsive QPThydrogel platform has great potential for treating diabetic wounds. x n n x

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Tunicate cellulose nanocrystals strengthened injectable stretchable hydrogel as multi-responsive enhanced antibacterial wound dressing for promoting diabetic wound healing

Abstract

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