Biomimetic Skin Inspired by Turritopsis nutricula May Help Heal Aged Wounds by Changing Mitochondrial Metabolism Through DAZAP1 Phase Separation

Biomimetic skin incorporating amino-functionalized apoptotic bodies may effectively enhance wound healing in aged individuals.

• The biomimetic skin matrix (BSM) was created from human adipose tissue and combined with apoptotic bodies.
• BSM@FABs demonstrated a strong affinity for fibroblasts, which are crucial for wound healing.
• This combination reversed cellular aging, accelerated cell movement, and stimulated new blood vessel formation in wounds.
• A novel liquid-liquid phase separation process was identified that enhances mitochondrial energy metabolism.
• The approach may improve mitochondrial function by increasing energy production while reducing harmful byproducts.

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