Ulva lactuca polysaccharides combined with fecal microbiota transplantation ameliorated dextran sodium sulfate‐induced colitis in C57BL/6J mice

Aug 30, 2024Journal of the science of food and agriculture

Seaweed sugars combined with gut bacteria transplant improved chemically caused gut inflammation in mice

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Abstract

Supplementation with Ulva lactuca polysaccharides (ULP) combined with fecal microbiota transplantation (FMT) significantly improved ulcerative colitis (UC) symptoms in mice compared to FMT alone.

Combination treatment with ULP and FMT prevented body weight loss and improved the disease activity index in mice with UC.
ULP in conjunction with FMT was more effective in reducing levels of inflammatory cytokines and enzymes associated with inflammation.
The combination effectively restored gut microbiota balance disrupted by dextran sulfate sodium (DSS), enriching beneficial probiotics like Bifidobacterium.
Significantly higher production of short-chain fatty acids, particularly acetic acid, was observed with ULP combined with FMT.

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BACKGROUND: Fecal microbiota transplantation (FMT) of healthy donors improves ulcerative colitis (UC) patients by restoring the balance of the gut microbiota. However, donors vary in microbial diversity and composition, often resulting in weak or even ineffective FMT. Improving the efficacy of FMT through combination treatment has become a promising strategy. Ulva lactuca polysaccharides (ULP) have been found to benefit host health by regulating gut microbiota. The effect of the combination of ULP and FMT in ameliorating UC has not yet been evaluated.

RESULTS: The present study found that supplementation with ULP combined with FMT showed better effects in ameliorating UC than supplementation with FMT alone. Results suggested that FMT or ULP combined with FMT alleviated the symptoms of UC in mice, as evidenced by prevention of body weight loss, improvement of disease activity index and protection of the intestinal mucus. Notably, ULP in combination with FMT was more effective than FMT in reducing levels of cytokines and related inflammatory enzymes. In addition, ULP combined with FMT effectively restored the dysbiosis induced by dextran sulfate sodium (DSS) and further enriched probiotics (such as Bifidobacterium). The production of short-chain fatty acids, especially acetic acid, was also significantly enriched by ULP combined with FMT.

CONCLUSION: Supplementation of ULP combined with FMT could significantly ameliorate DSS-induced colitis in mice by inhibiting inflammation and restoring dysbiosis of gut microbiota. These results suggested that ULP combined with FMT has potential application in ameliorating UC. © 2024 Society of Chemical Industry.

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Ulva lactuca polysaccharides combined with fecal microbiota transplantation ameliorated dextran sodium sulfate‐induced colitis in C57BL/6J mice

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