In vivo (Athens, Greece)Oct 29, 2026

Urolithin A reduces noise-related hearing loss and is linked to increased cell cleanup in the ear

Longevity & Aging Weekly Brief ↗PubMed ↗DOI ↗

Updated Nov 2, 2026

Abstract

Urolithin A (UA) may protect against noise-induced hearing loss (NIHL) by inducing mitophagy.

Noise-induced hearing loss is a common cause of sensorineural hearing impairment.
Mitochondrial dysfunction is implicated in the development of NIHL.
Mitophagy is crucial for maintaining the health of mitochondria.
Urolithin A is recognized as a mitophagy inducer.

Simplified

Noise-induced hearing loss (NIHL) is a prevalent cause of sensorineural hearing impairment, in which mitochondrial dysfunction plays a key pathogenic role. Mitophagy is essential for maintaining mitochondrial quality control. This study investigated whether urolithin A (UA), a known mitophagy inducer, protects against NIHL.

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Urolithin A reduces noise-related hearing loss and is linked to increased cell cleanup in the ear

Abstract

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